Production of Infectious Genotype 1b Virus Particles in Cell Culture and Impairment by Replication Enhancing Mutations

With the advent of subgenomic hepatitis C virus (HCV) replicons, studies of the intracellular steps of the viral replication cycle became possible. These RNAs are capable of self-amplification in cultured human hepatoma cells, but save for the genotype 2a isolate JFH-1, efficient replication of thes...

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Bibliographische Detailangaben
Hauptverfasser: Pietschmann, Thomas, Zayas, Margarita, Meuleman, Philip, Long, Gang, Appel, Nicole, Koutsoudakis, George, Kallis, Stephanie, Leroux-Roels, Geert, Lohmann, Volker, Bartenschlager, Ralf
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2009
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2691593/
https://ncbi.nlm.nih.gov/pubmed/19521536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000475
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