Development and Characterization of a Genotype 4 Hepatitis E Virus Cell Culture System Using a HE-JF5/15F Strain Recovered from a Fulminant Hepatitis Patient

We developed an efficient cell culture system for genotype 4 hepatitis E virus using the HE-JF5/15F strain recovered from a fulminant hepatitis patient. The sixth-passage virus in the culture supernatant reached 1.5 × 10(8) copies/ml at 10 days postinoculation and possessed 10 nucleotide mutations w...

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Bibliografiske detaljer
Main Authors: Tanaka, Toshinori, Takahashi, Masaharu, Takahashi, Hideyuki, Ichiyama, Koji, Hoshino, Yu, Nagashima, Shigeo, Mizuo, Hitoshi, Okamoto, Hiroaki
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
Fag:
Virology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2691090/
https://ncbi.nlm.nih.gov/pubmed/19369433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.00629-09
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