Molecular interactions in rotavirus assembly and uncoating seen by high-resolution cryo-EM

Rotaviruses, major causes of childhood gastroenteritis, are nonenveloped, icosahedral particles with double-strand RNA genomes. By the use of electron cryomicroscopy and single-particle reconstruction, we have visualized a rotavirus particle comprising the inner capsid coated with the trimeric outer...

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Bibliographic Details
Main Authors: Chen, James Z., Settembre, Ethan C., Aoki, Scott T., Zhang, Xing, Bellamy, A. Richard, Dormitzer, Philip R., Harrison, Stephen C., Grigorieff, Nikolaus
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2689313/
https://ncbi.nlm.nih.gov/pubmed/19487668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0904024106
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