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ErbB2-mediated Src and STAT3 Activation Leads to Transcriptional Upregulation of p21(Cip1) and Chemoresistance in Breast Cancer Cells
Overexpression of the ErbB2 receptor tyrosine kinase is prevalent in approximately 30% of human breast cancers and confers Taxol resistance. Our previous work has demonstrated that ErbB2 inhibits Taxol induced apoptosis in breast cancer cells by transcriptionally upregulating p21(Cip1). However, the...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2689096/ https://ncbi.nlm.nih.gov/pubmed/19372587 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-08-0316 |
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