Functional Characterization of Genetic Variation in the Frizzled 1 (FZD1) Promoter and Association With Bone Phenotypes: More to the LRP5 Story?

WNT signaling is an important determinant of bone formation. The WNT co-receptor, Frizzled homolog 1 (FZD1), initiates WNT signal transduction. To study the influence of FZD1 genetic variation on measures of bone health, we first sequenced a 6.8-kb region surrounding FZD1 in 48 samples of African an...

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Hlavní autoři: Yerges, Laura M, Zhang, Yingze, Cauley, Jane A, Kammerer, Candace M, Nestlerode, Cara S, Wheeler, Victor W, Patrick, Alan L, Bunker, Clareann H, Moffett, Susan P, Ferrell, Robert E, Zmuda, Joseph M
Médium: Artigo
Jazyk:Inglês
Vydáno: Amer Soc Bone & Mineral Res. 2009
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2689083/
https://ncbi.nlm.nih.gov/pubmed/18715140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1359/JBMR.080816
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