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The pathway of HCV mRNA recruitment to the human ribosome

Eukaryotic protein synthesis begins with mRNA positioning in the ribosomal decoding channel in a process typically controlled by translation initiation factors. Some viruses utilize an internal ribosome entry site (IRES) in their mRNA to harness ribosomes independently of initiation factors. We show...

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Bibliographic Details
Main Authors: Fraser, Christopher S., Hershey, John W. B., Doudna, Jennifer A.
Format: Artigo
Language:Inglês
Published: 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2689074/
https://ncbi.nlm.nih.gov/pubmed/19287397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1572
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