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Dopamine-induced proliferation of adult neural precursor cells in the mammalian subventricular zone is mediated through EGF

A reduction in dopaminergic innervation of the subventricular zone (SVZ) is responsible for the impaired proliferation of its resident precursor cells in this region in Parkinson's disease (PD). Here, we show that this effect involves EGF, but not FGF2. In particular, we demonstrate that dopami...

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Autores principales: O'Keeffe, Gráinne C., Tyers, Pam, Aarsland, Dag, Dalley, Jeffrey W., Barker, Roger A., Caldwell, Maeve A.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2689002/
https://ncbi.nlm.nih.gov/pubmed/19433789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803955106
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