PDK1 coordinates survival pathways and β-adrenergic response in the heart

The 3-phosphoinositide-dependent kinase-1 (PDK1) plays an important role in the regulation of cellular responses in multiple organs by mediating the phosphoinositide 3-kinase (PI3-K) signaling pathway through activating AGC kinases. Here we defined the role of PDK1 in controlling cardiac homeostasis...

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Hlavní autoři: Ito, Kaoru, Akazawa, Hiroshi, Tamagawa, Masaji, Furukawa, Kensuke, Ogawa, Wataru, Yasuda, Noritaka, Kudo, Yoko, Liao, Chien-hui, Yamamoto, Rie, Sato, Toshiaki, Molkentin, Jeffery D., Kasuga, Masato, Noda, Tetsuo, Nakaya, Haruaki, Komuro, Issei
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2009
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2688981/
https://ncbi.nlm.nih.gov/pubmed/19429709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0900064106
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