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The type III TGF-β receptor regulates epithelial and cancer cell migration through β-arrestin2-mediated activation of Cdc42

Loss of expression of the TGF-β superfamily coreceptor, the type III TGF-β receptor (TβRIII or betaglycan), occurs in a broad spectrum of human cancers including breast, lung, ovarian, pancreatic, prostate, and renal cell cancer. TβRIII suppresses cancer progression in vivo, at least in part, by red...

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Detalhes bibliográficos
Main Authors: Mythreye, Karthikeyan, Blobe, Gerard C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2688894/
https://ncbi.nlm.nih.gov/pubmed/19416857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812879106
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