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Apoptosis of CD4(+)CD25(high) T cells in response to Sirolimus requires activation of T Cell Receptor and is modulated by IL-2
Targeted molecular therapies inhibit cancer cell proliferation and survival but may interfere with proliferation and survival of lymphoid cells. Treatment with Sirolimus or Sorafenib was cytotoxic to CD4(+)CD25(high) T cells, and was growth inhibitory for CD4(+) and CD8(+) T cells. The cytotoxicity...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2688807/ https://ncbi.nlm.nih.gov/pubmed/18841360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-008-0602-6 |
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