Intrinsic impaired proplatelet formation and microtubule coil assembly of megakaryocytes in a mouse model of Bernard-Soulier syndrome

BACKGROUND: Giant platelets and thrombocytopenia are invariable defects in the Bernard-Soulier syndrome caused by deficiency of the GPIb-V-IX complex, a receptor for von Willebrand factor supporting platelet adhesion to the damaged arterial wall. Various properties of this receptor may be considered...

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Autores principales: Strassel, Catherine, Eckly, Anita, Léon, Catherine, Petitjean, Claire, Freund, Monique, Cazenave, Jean-Pierre, Gachet, Christian, Lanza, François
Formato: Artigo
Lenguaje:Inglês
Publicado: Ferrata Storti Foundation 2009
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2688571/
https://ncbi.nlm.nih.gov/pubmed/19377075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2008.001032
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