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Reduced c-Myb activity compromises HSCs and leads to a myeloproliferation with a novel stem cell basis
Murine haematopoietic stem cells (HSCs) are contained in the Kit(+)Sca1(+)Lin(−) (KSL) population of bone marrow and are able to repopulate lethally irradiated mice. Myeloproliferative disorders (MPDs) are thought to be clonogenic diseases arising at the level of the HSC. Here, we show that mice exp...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2688541/ https://ncbi.nlm.nih.gov/pubmed/19360001 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.97 |
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