ChIP-Seq of ERα and RNA polymerase II defines genes differentially responding to ligands

We used ChIP-Seq to map ERα-binding sites and to profile changes in RNA polymerase II (RNAPII) occupancy in MCF-7 cells in response to estradiol (E2), tamoxifen or fulvestrant. We identify 10 205 high confidence ERα-binding sites in response to E2 of which 68% contain an estrogen response element (E...

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Main Authors: Welboren, Willem-Jan, van Driel, Marc A, Janssen-Megens, Eva M, van Heeringen, Simon J, Sweep, Fred CGJ, Span, Paul N, Stunnenberg, Hendrik G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2688537/
https://ncbi.nlm.nih.gov/pubmed/19339991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.88
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