Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis

INTRODUCTION: Septic encephalopathy secondary to a breakdown of the blood-brain barrier (BBB) is a known complication of sepsis. However, its pathophysiology remains unclear. The present study investigated the effect of complement C5a blockade in preventing BBB damage and pituitary dysfunction durin...

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Detalhes bibliográficos
Main Authors: Flierl, Michael A, Stahel, Philip F, Rittirsch, Daniel, Huber-Lang, Markus, Niederbichler, Andreas D, Hoesel, L Marco, Touban, Basel M, Morgan, Steven J, Smith, Wade R, Ward, Peter A, Ipaktchi, Kyros
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2688129/
https://ncbi.nlm.nih.gov/pubmed/19196477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc7710
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