Identifying novel constrained elements by exploiting biased substitution patterns

Motivation: Comparing the genomes from closely related species provides a powerful tool to identify functional elements in a reference genome. Many methods have been developed to identify conserved sequences across species; however, existing methods only model conservation as a decrease in the rate...

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Bibliographic Details
Main Authors: Garber, Manuel, Guttman, Mitchell, Clamp, Michele, Zody, Michael C., Friedman, Nir, Xie, Xiaohui
Format: Artigo
Language:Inglês
Published: Oxford University Press 2009
Subjects:
Ismb/Eccb 2009 Conference Proceedings June 27 to July 2, 2009, Stockholm, Sweden
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2687944/
https://ncbi.nlm.nih.gov/pubmed/19478016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btp190
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