Interleukin-12 (IL-12), but Not IL-23, Deficiency Ameliorates Viral Encephalitis without Affecting Viral Control

The relative contributions of interleukin-12 (IL-12) and IL-23 to viral pathogenesis have not been extensively studied. IL-12p40 mRNA rapidly increases after neurotropic coronavirus infection. Infection of mice defective in both IL-12 and IL-23 (p40(−/−)), in IL-12 alone (p35(−/−)), and in IL-23 alo...

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Main Authors: Kapil, Parul, Atkinson, Roscoe, Ramakrishna, Chandran, Cua, Daniel J., Bergmann, Cornelia C., Stohlman, Stephen A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2687402/
https://ncbi.nlm.nih.gov/pubmed/19339350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00315-09
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