Mutations in Hepatitis C Virus E2 Located outside the CD81 Binding Sites Lead to Escape from Broadly Neutralizing Antibodies but Compromise Virus Infectivity

Broadly neutralizing antibodies are commonly present in the sera of patients with chronic hepatitis C virus (HCV) infection. To elucidate possible mechanisms of virus escape from these antibodies, retrovirus particles pseudotyped with HCV glycoproteins (HCVpp) isolated from sequential samples collec...

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Detalhes bibliográficos
Main Authors: Keck, Zhen-yong, Li, Sophia H., Xia, Jinming, von Hahn, Thomas, Balfe, Peter, McKeating, Jane A., Witteveldt, Jeroen, Patel, Arvind H., Alter, Harvey, Rice, Charles M., Foung, Steven K. H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Genetic Diversity and Evolution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2687388/
https://ncbi.nlm.nih.gov/pubmed/19321602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00248-09
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