Baseline expression of α4 β2* nicotinic acetylcholine receptors predicts motivation to self-administer nicotine

BACKGROUND: Marked inter-individual differences in vulnerability to nicotine dependence exist, but factors underlying such differences are not well understood. The midbrain α4β2* subtype of nicotinic acetylcholine receptors (nAChRs) has been implicated in mediation of the reinforcing effects of nico...

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Autori principali: Le Foll, Bernard, Chefer, Svetlana I., Kimes, Alane S., Shumway, Dean, Stein, Elliot A., Mukhin, Alexey G., Goldberg, Steven R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2687082/
https://ncbi.nlm.nih.gov/pubmed/19095220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2008.09.036
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