Thrombin induces Egr-1 expression in fibroblasts involving elevation of the intracellular Ca(2+ )concentration, phosphorylation of ERK and activation of ternary complex factor

BACKGROUND: The serine protease thrombin catalyzes fibrin clot formation by converting fibrinogen into fibrin. Additionally, thrombin stimulation leads to an activation of stimulus-responsive transcription factors in different cell types, indicating that the gene expression pattern is changed in thr...

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Hlavní autoři: Rössler, Oliver G, Thiel, Gerald
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2009
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2686679/
https://ncbi.nlm.nih.gov/pubmed/19432968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-10-40
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