Signal Transduction of Pregnenolone Sulfate in Insulinoma Cells: ACTIVATION OF EGR-1 EXPRESSION INVOLVING TRPM3, VOLTAGE-GATED CALCIUM CHANNELS, ERK, AND TERNARY COMPLEX FACTORS

The neurosteroid pregnenolone sulfate acts on the nervous system by modifying neurotransmission and receptor functions, thus influencing synaptic strength, neuronal survival, and neurogenesis. Here we show that pregnenolone sulfate induces a signaling cascade in insulinoma cells leading to enhanced...

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Détails bibliographiques
Auteurs principaux: Mayer, Sabine I., Müller, Isabelle, Mannebach, Stefanie, Endo, Takeshi, Thiel, Gerald
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2011
Sujets:
Signal Transduction
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060460/
https://ncbi.nlm.nih.gov/pubmed/21257751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.202697
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