Assessment of a pharmacokinetic and pharmacodynamic interaction between simvastatin and anacetrapib, a potent cholesteryl ester transfer protein (CETP) inhibitor, in healthy subjects

AIMS: Anacetrapib is an orally active, potent inhibitor of cholesteryl ester transfer protein (CETP), which is in development for the treatment of dyslipidaemia. Because of the likely use of anacetrapib with hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, we aimed to evaluate the potential...

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Detalles Bibliográficos
Main Authors: Krishna, Rajesh, Garg, Amit, Jin, Bo, Keshavarz, Sara Sadeghi, Bieberdorf, Frederick A, Chodakewitz, Jeffrey, Wagner, John A
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2009
Assuntos:
Drug Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2686068/
https://ncbi.nlm.nih.gov/pubmed/19552746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2009.03385.x
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