TNFα-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish s-adenosylhomocysteine hydrolase

Hepatic steatosis and liver degeneration are prominent features of the zebrafish ducttrip (dtp) mutant phenotype. Positional cloning identified a causative mutation in the gene encoding S-adenosylhomocysteine hydrolase (Ahcy). Reduced Ahcy activity in dtp mutants led to elevated levels of S-adenosyl...

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Detalhes bibliográficos
Main Authors: Matthews, Randolph P., Lorent, Kristin, Mañoral-Mobias, Rafael, Huang, Yuehua, Gong, Weilong, Murray, Ian V. J., Blair, Ian A., Pack, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Company of Biologists 2009
Assuntos:
Development and Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685951/
https://ncbi.nlm.nih.gov/pubmed/19201949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.027565
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