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Regulation of the Rac GTPase pathway by the multifunctional Rho GEF Pebble is essential for mesoderm migration in the Drosophila gastrula

The Drosophila guanine nucleotide exchange factor Pebble (Pbl) is essential for cytokinesis and cell migration during gastrulation. In dividing cells, Pbl promotes Rho1 activation at the cell cortex, leading to formation of the contractile actin-myosin ring. The role of Pbl in fibroblast growth fact...

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Autors principals: van Impel, Andreas, Schumacher, Sabine, Draga, Margarethe, Herz, Hans-Martin, Großhans, Jörg, Müller, H. Arno J.
Format: Artigo
Idioma:Inglês
Publicat: Company of Biologists 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685947/
https://ncbi.nlm.nih.gov/pubmed/19176590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.026203
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