Telomerase-associated Protein 1, HSP90, and Topoisomerase IIα Associate Directly with the BLM Helicase in Immortalized Cells Using ALT and Modulate Its Helicase Activity Using Telomeric DNA Substrates

The BLM helicase associates with the telomere structural proteins TRF1 and TRF2 in immortalized cells using the alternative lengthening of telomere (ALT) pathways. This work focuses on identifying protein partners of BLM in cells using ALT. Mass spectrometry and immunoprecipitation techniques have i...

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Detalhes bibliográficos
Main Authors: Bhattacharyya, Saumitri, Keirsey, Jeremy, Russell, Beatriz, Kavecansky, Juraj, Lillard-Wetherell, Kate, Tahmaseb, Kambiz, Turchi, John J., Groden, Joanna
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685679/
https://ncbi.nlm.nih.gov/pubmed/19329795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M900195200
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