Changes in Sodium Pump Expression Dictate the Effects of Ouabain on Cell Growth

Here we show that ouabain-induced cell growth regulation is intrinsically coupled to changes in the cellular amount of Na/K-ATPase via the phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway. Ouabain increases the endocytosis and degradation of Na/K-ATPase in LLC-PK1, h...

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Main Authors: Tian, Jiang, Li, Xin, Liang, Man, Liu, Lijun, Xie, Joe X., Ye, Qiqi, Kometiani, Peter, Tillekeratne, Manoranjani, Jin, Runming, Xie, Zijian
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
Mechanisms of Signal Transduction
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685674/
https://ncbi.nlm.nih.gov/pubmed/19329430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808355200
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