Stretch-activated channel activation promotes early afterdepolarizations in rat ventricular myocytes under oxidative stress

Mechanical stretch and oxidative stress have been shown to prolong action potential duration (APD) and produce early afterdepolarizations (EADs). Here, we developed a simulation model to study the role of stretch-activated channel (SAC) currents in triggering EADs in ventricular myocytes under oxida...

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Bibliographic Details
Main Authors: Wang, Yanggan, Joyner, Ronald W., Wagner, Mary B., Cheng, Jun, Lai, Dongwu, Crawford, Brian H.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2009
Subjects:
Translational Physiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685334/
https://ncbi.nlm.nih.gov/pubmed/19286952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00808.2008
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