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Stretch-activated channel activation promotes early afterdepolarizations in rat ventricular myocytes under oxidative stress

Mechanical stretch and oxidative stress have been shown to prolong action potential duration (APD) and produce early afterdepolarizations (EADs). Here, we developed a simulation model to study the role of stretch-activated channel (SAC) currents in triggering EADs in ventricular myocytes under oxida...

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Hlavní autoři: Wang, Yanggan, Joyner, Ronald W., Wagner, Mary B., Cheng, Jun, Lai, Dongwu, Crawford, Brian H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685334/
https://ncbi.nlm.nih.gov/pubmed/19286952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00808.2008
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