Magnesium-dependent folding of self-splicing RNA: Exploring the link between cooperativity, thermodynamics, and kinetics

Folding of the Tetrahymena self-splicing RNA into its active conformation involves a set of discrete intermediate states. The Mg(2+)-dependent equilibrium transition from the intermediates to the native structure is more cooperative than the formation of the intermediates from the unfolded states. W...

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Bibliographic Details
Main Authors: Pan, Jie, Thirumalai, D., Woodson, Sarah A.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 1999
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC26850/
https://ncbi.nlm.nih.gov/pubmed/10339556
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