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Steroid Interaction with a Single Potentiating Site Is Sufficient to Modulate GABA-A Receptor Function
Neuroactive steroids are efficacious potentiators of GABA-A receptors. Recent work has identified a site in the α1 subunit of the GABA-A receptor, that is essential for potentiation by steroids. However, each receptor contains two copies of the α1 subunit. We generated concatemers of subunits so tha...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Pharmacology and Experimental Therapeutics
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2684936/ https://ncbi.nlm.nih.gov/pubmed/19176850 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.053629 |
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