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Targeting Protein Serine/Threonine Phosphatases for Drug Development

With the recent clinical success of drugs targeting protein kinase activity, drug discovery efforts are focusing on the role of reversible protein phosphorylation in disease states. The activity of protein phosphatases, enzymes that oppose protein kinases, can also be manipulated to alter cellular s...

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Detalhes bibliográficos
Main Authors: McConnell, Jamie L., Wadzinski, Brian E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Pharmacology and Experimental Therapeutics 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684880/
https://ncbi.nlm.nih.gov/pubmed/19299564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.053140
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