HDAC6 Modulates Cell Motility by Altering the Acetylation Level of Cortactin

Histone deacetylase 6 (HDAC6) is a tubulin-specific deacetylase that regulates microtubule-dependent cell movement. In this study, we identify the F-actin-binding protein, cortactin, as a HDAC6 substrate. We demonstrate that HDAC6 binds cortactin and that overexpression of HDAC6 leads to hypoacetyla...

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Bibliografiske detaljer
Main Authors: Zhang, Xiaohong, Yuan, Zhigang, Zhang, Yingtao, Yong, Sarah, Salas-Burgos, Alexis, Koomen, John, Olashaw, Nancy, Parsons, J. Thomas, Yang, Xiang-Jiao, Dent, Sharon R., Yao, Tso-Pang, Lane, William S., Seto, Edward
Format: Artigo
Sprog:Inglês
Udgivet: 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684874/
https://ncbi.nlm.nih.gov/pubmed/17643370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.05.033
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