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Shiga Toxin 2 Affects the Central Nervous System Through Receptor Gb(3) Localized to Neurons
Affinity purified Shiga toxin 2 (Stx2) i.p. to mice caused weight loss and hind limb paralysis followed by death. Globotriaosylceramide (Gb(3)), the receptor for Stx2, was localized to neurons of the central nervous system (CNS) of normal mice. Gb(3) was not found in astrocytes nor endothelial cells...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2684825/ https://ncbi.nlm.nih.gov/pubmed/18754742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/591911 |
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