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Suppression of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Nitric-Oxide Synthase 2 Expression in Astrocytes by a Novel Diindolylmethane Analog Protects Striatal Neurons against Apoptosis

The progressive debilitation of motor functions in Parkinson's disease (PD) results from degeneration of dopaminergic neurons within the substantia nigra pars compacta of the midbrain. Long-term inflammatory activation of microglia and astrocytes plays a central role in the progression of PD an...

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Main Authors: Carbone, David. L., Popichak, Katriana A., Moreno, Julie A., Safe, Stephen, Tjalkens, Ronald B.
格式: Artigo
語言:Inglês
出版: American Society for Pharmacology and Experimental Therapeutics 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684683/
https://ncbi.nlm.nih.gov/pubmed/18840677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.050781
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