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Suppression of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Nitric-Oxide Synthase 2 Expression in Astrocytes by a Novel Diindolylmethane Analog Protects Striatal Neurons against Apoptosis

The progressive debilitation of motor functions in Parkinson's disease (PD) results from degeneration of dopaminergic neurons within the substantia nigra pars compacta of the midbrain. Long-term inflammatory activation of microglia and astrocytes plays a central role in the progression of PD an...

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Главные авторы: Carbone, David. L., Popichak, Katriana A., Moreno, Julie A., Safe, Stephen, Tjalkens, Ronald B.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Pharmacology and Experimental Therapeutics 2009
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684683/
https://ncbi.nlm.nih.gov/pubmed/18840677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.050781
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