Suppression of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Nitric-Oxide Synthase 2 Expression in Astrocytes by a Novel Diindolylmethane Analog Protects Striatal Neurons against Apoptosis

The progressive debilitation of motor functions in Parkinson's disease (PD) results from degeneration of dopaminergic neurons within the substantia nigra pars compacta of the midbrain. Long-term inflammatory activation of microglia and astrocytes plays a central role in the progression of PD an...

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Autores principales: Carbone, David. L., Popichak, Katriana A., Moreno, Julie A., Safe, Stephen, Tjalkens, Ronald B.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Pharmacology and Experimental Therapeutics 2009
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684683/
https://ncbi.nlm.nih.gov/pubmed/18840677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.050781
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