Suppression of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Nitric-Oxide Synthase 2 Expression in Astrocytes by a Novel Diindolylmethane Analog Protects Striatal Neurons against Apoptosis

Eitemau Tebyg

• Importance of monoamine oxidase A in the bioactivation of neurotoxic analogs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
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• Novel Para-Phenyl Substituted Diindolylmethanes Protect Against MPTP Neurotoxicity and Suppress Glial Activation in a Mouse Model of Parkinson’s Disease
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  Cyhoeddwyd: (2015)
• Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity.
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• Low-Dose 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Causes Inflammatory Activation of Astrocytes in Nuclear Factor-κB Reporter Mice Prior to Loss of Dopaminergic Neurons
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  Cyhoeddwyd: (2011)
• A novel diindolylmethane analog, 1,1-bis(3′-indolyl)-1-(p-chlorophenyl) methane, inhibits the tumor necrosis factor-induced inflammatory response in primary murine synovial fibroblasts through a Nurr1-dependent mechanism
  gan: Afzali, Maryam F., et al.
  Cyhoeddwyd: (2018)