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Mistranslation of membrane proteins and two-component system activation trigger aminoglycoside-mediated oxidative stress and cell death
Aminoglycoside antibiotics directly target the ribosome, yet the mechanisms by which they induce cell death are not fully understood. Recently, oxidative stress has been implicated as one of the mechanisms whereby bactericidal antibiotics kill bacteria. Here we work out, using systems-level approach...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2684502/ https://ncbi.nlm.nih.gov/pubmed/19013277 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.09.038 |
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