Platelet-Derived Hyaluronidase 2 Cleaves Hyaluronan into Fragments that Trigger Monocyte-Mediated Production of Proinflammatory Cytokines

Hyaluronan (HA) occurs in the body as a large, hydrating, space-filling, carbohydrate polymer in the extracellular matrix; it has both anti-angiogenic and immunosuppressive properties. Cleavage of HA results in the generation of variably sized fragments that stimulate multiple angiogenic and inflamm...

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Detalhes bibliográficos
Main Authors: de la Motte, Carol, Nigro, Julie, Vasanji, Amit, Rho, Hyunjin, Kessler, Sean, Bandyopadhyay, Sudip, Danese, Silvio, Fiocchi, Claudio, Stern, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2009
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684190/
https://ncbi.nlm.nih.gov/pubmed/19443707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080831
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