Combined Sensitization of Mice to Extracts of Dust Mites, Ragweed and Aspergillus Breaks through Tolerance and Establishes Chronic Features of Asthma in Mice

BACKGROUND: Existing asthma models develop tolerance when chronically exposed to the same allergen. OBJECTIVE: To establish a chronic model that sustains features of asthma long after discontinuation of allergen exposure. METHODS: We immunized and exposed mice to a combination of single, double or t...

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Detalhes bibliográficos
Main Authors: Goplen, Nicholas, Karim, M. Zunayet, Liang, Qiaoling, Gorska, Magdalena M, Rozario, Sadee, Guo, Lei, Alam, Rafeul
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683988/
https://ncbi.nlm.nih.gov/pubmed/19348928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2009.02.009
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