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Protein Electrophile-Binding Motifs: Lysine-Rich Proteins Are Preferential Targets of Quinones

Quinones represent an important class of endogenous compounds such as neurotransmitters and coenzyme Q10, electrophilic xenobiotics, and environmental toxicants that have known reactivity based on their ability to redox cycle and generate oxidative stress, as well as to alkylate target proteins. It...

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Autori principali: Labenski, Matthew T., Fisher, Ashley A., Lo, Herng-Hsiang, Monks, Terrence J., Lau, Serrine S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Pharmacology and Experimental Therapeutics 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683689/
https://ncbi.nlm.nih.gov/pubmed/19251821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.026211
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