SLC30A3 Responds to Glucose- and Zinc Variations in ß-Cells and Is Critical for Insulin Production and In Vivo Glucose-Metabolism During ß-Cell Stress

BACKGROUND: Ion transporters of the Slc30A- (ZnT-) family regulate zinc fluxes into sub-cellular compartments. β-cells depend on zinc for both insulin crystallization and regulation of cell mass. METHODOLOGY/PRINCIPAL FINDINGS: This study examined: the effect of glucose and zinc chelation on ZnT gen...

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Detalhes bibliográficos
Main Authors: Smidt, Kamille, Jessen, Niels, Petersen, Andreas Brønden, Larsen, Agnete, Magnusson, Nils, Jeppesen, Johanne Bruun, Stoltenberg, Meredin, Culvenor, Janetta G., Tsatsanis, Andrew, Brock, Birgitte, Schmitz, Ole, Wogensen, Lise, Bush, Ashley I., Rungby, Jørgen
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683566/
https://ncbi.nlm.nih.gov/pubmed/19492079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005684
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