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MUTATIONS IN SUB-DOMAIN B OF THE MCM HELICASE AFFECT DNA BINDING AND MODULATE CONFORMATIONAL TRANSITIONS
Minichromosome maintenance (MCM) proteins are believed to provide the replicative helicase activity in eukaryotes and archaea. The single MCM orthologue from Methanothermobacter thermautotrophicus (MthMCM) has been extensively characterised as a model of the eukaryotic heterohexameric MCM complex. M...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2683335/ https://ncbi.nlm.nih.gov/pubmed/19116205 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806973200 |
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