The Carboxyl-terminal Domain of Atypical Protein Kinase Cζ Binds to Ceramide and Regulates Junction Formation in Epithelial Cells

Atypical protein kinase Cs (PKCs) (aPKCζ and λ/ι) have emerged as important binding partners for ceramide, a membrane-resident cell signaling lipid that is involved in the regulation of apoptosis as well as cell polarity. Using ceramide overlay assays with proteolytic fragments of PKCζ and vesicle b...

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Bibliographic Details
Main Authors: Wang, Guanghu, Krishnamurthy, Kannan, Umapathy, Nagavedi S., Verin, Alexander D., Bieberich, Erhard
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Molecular Basis of Cell and Developmental Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682895/
https://ncbi.nlm.nih.gov/pubmed/19304661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808909200
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