Real-time Analysis of Conformation-sensitive Antibody Binding Provides New Insights into Integrin Conformational Regulation

Integrins are heterodimeric adhesion receptors that regulate immune cell adhesion. Integrin-dependent adhesion is controlled by multiple conformational states that include states with different affinity to the ligand, states with various degrees of molecule unbending, and others. Affinity change and...

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Autors principals: Chigaev, Alexandre, Waller, Anna, Amit, Or, Halip, Liliana, Bologa, Cristian G., Sklar, Larry A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
Matèries:
Molecular Basis of Cell and Developmental Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682882/
https://ncbi.nlm.nih.gov/pubmed/19251697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M901178200
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