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Combination Therapy Using Chimeric Monoclonal Antibodies Protects Mice from Lethal H5N1 Infection and Prevents Formation of Escape Mutants

BACKGROUND: Given that there is a possibility of a human H5N1 pandemic and the fact that the recent H5N1 viruses are resistant to the anti-viral drugs, newer strategies for effective therapy are warranted. Previous studies show that single mAbs in immune prophylaxis can be protective against H5N1 in...

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Autors principals: Prabakaran, Mookkan, Prabhu, Nayana, He, Fang, Hongliang, Qian, Ho, Hui-Ting, Qiang, Jia, TaoMeng, Goutama, Michael, Kwang, Jimmy
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682562/
https://ncbi.nlm.nih.gov/pubmed/19478856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005672
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