Ethanol Withdrawal Provokes Opening of the Mitochondrial Membrane Permeability Transition Pore in an Estrogen-Preventable Manner

We have reported that the major endogenous estrogen, 17β-estradiol (E2), protects against oxidative injury during ethanol withdrawal (EW) in a cultured hippocampal cell line (HT22). Here, we investigated whether the pro-oxidant nature of EW mediates opening of the mitochondrial membrane permeability...

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Bibliographic Details
Main Authors: Jung, Marianna E., Wilson, Andrew M., Ju, Xiaohua, Wen, Yi, Metzger, Daniel B., Simpkins, James W.
Format: Artigo
Language:Inglês
Published: American Society for Pharmacology and Experimental Therapeutics 2009
Subjects:
Neuropharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682266/
https://ncbi.nlm.nih.gov/pubmed/19050172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.146829
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