Simulating Henipavirus Multicycle Replication in a Screening Assay Leads to Identification of a Promising Candidate for Therapy

Nipah (NiV) and Hendra (HeV) viruses are emerging zoonotic paramyxoviruses that cause encephalitis in humans, with fatality rates of up to 75%. We designed a new high-throughput screening (HTS) assay for inhibitors of infection based on envelope glycoprotein pseudotypes. The assay simulates multicyc...

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Detalhes bibliográficos
Main Authors: Porotto, Matteo, Orefice, Gianmarco, Yokoyama, Christine C., Mungall, Bruce A., Realubit, Ronald, Sganga, Michael L., Aljofan, Mohamad, Whitt, Michael, Glickman, Fraser, Moscona, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682105/
https://ncbi.nlm.nih.gov/pubmed/19264786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00164-09
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