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Regulation of p53 by TopBP1: a Potential Mechanism for p53 Inactivation in Cancer
Proper control of the G(1)/S checkpoint is essential for normal proliferation. The activity of p53 must be kept at a very low level under unstressed conditions to allow growth. Here we provide evidence supporting a crucial role for TopBP1 in actively repressing p53. Depletion of TopBP1 upregulates p...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Microbiology (ASM)
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2682038/ https://ncbi.nlm.nih.gov/pubmed/19289498 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01140-08 |
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