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PLRG1 Is an Essential Regulator of Cell Proliferation and Apoptosis during Vertebrate Development and Tissue Homeostasis

PLRG1, an evolutionarily conserved component of the spliceosome, forms a complex with Pso4/SNEV/Prp19 and the cell division and cycle 5 homolog (CDC5L) that is involved in both pre-mRNA splicing and DNA repair. Here, we show that the inactivation of PLRG1 in mice results in embryonic lethality at 1....

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Autors principals: Kleinridders, André, Pogoda, Hans-Martin, Irlenbusch, Sigrid, Smyth, Neil, Koncz, Csaba, Hammerschmidt, Matthias, Brüning, Jens C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682009/
https://ncbi.nlm.nih.gov/pubmed/19307306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01807-08
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