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Residues in a Highly Conserved Claudin-1 Motif Are Required for Hepatitis C Virus Entry and Mediate the Formation of Cell-Cell Contacts

Claudin-1, a component of tight junctions between liver hepatocytes, is a hepatitis C virus (HCV) late-stage entry cofactor. To investigate the structural and functional roles of various claudin-1 domains in HCV entry, we applied a mutagenesis strategy. Putative functional intracellular claudin-1 do...

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Main Authors: Cukierman, Lisa, Meertens, Laurent, Bertaux, Claire, Kajumo, Francis, Dragic, Tatjana
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681980/
https://ncbi.nlm.nih.gov/pubmed/19297469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02262-08
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