Recombinant Mycobacterium bovis BCG Prime-Recombinant Adenovirus Boost Vaccination in Rhesus Monkeys Elicits Robust Polyfunctional Simian Immunodeficiency Virus-Specific T-Cell Responses

While mycobacteria have been proposed as vaccine vectors because of their persistence and safety, little has been done systematically to optimize their immunogenicity in nonhuman primates. We successfully generated recombinant Mycobacterium bovis BCG (rBCG) expressing simian immunodeficiency virus (...

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Autors principals: Cayabyab, Mark J., Korioth-Schmitz, Birgit, Sun, Yue, Carville, Angela, Balachandran, Harikrishnan, Miura, Ayako, Carlson, Kevin R., Buzby, Adam P., Haynes, Barton F., Jacobs, William R., Letvin, Norman L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2009
Matèries:
Vaccines and Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681969/
https://ncbi.nlm.nih.gov/pubmed/19297477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02544-08
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